Bayesian hierarchical model of protein-binding microarray k-mer data reduces noise and identifies transcription factor subclasses and preferred k-mers.
Identifieur interne : 002047 ( Main/Exploration ); précédent : 002046; suivant : 002048Bayesian hierarchical model of protein-binding microarray k-mer data reduces noise and identifies transcription factor subclasses and preferred k-mers.
Auteurs : Bo Jiang [États-Unis] ; Jun S. Liu ; Martha L. BulykSource :
- Bioinformatics (Oxford, England) [ 1367-4811 ] ; 2013.
Descripteurs français
- KwdFr :
- Analyse de variance, Artéfacts, Facteurs de transcription (), Facteurs de transcription (métabolisme), Immunoprécipitation de la chromatine, Logiciel, Protéines de liaison à l'ADN (), Protéines de liaison à l'ADN (métabolisme), Sites de fixation, Séquençage par oligonucléotides en batterie (), Théorème de Bayes, Éléments de régulation transcriptionnelle.
- MESH :
- métabolisme : Facteurs de transcription, Protéines de liaison à l'ADN.
- Analyse de variance, Artéfacts, Facteurs de transcription, Immunoprécipitation de la chromatine, Logiciel, Protéines de liaison à l'ADN, Sites de fixation, Séquençage par oligonucléotides en batterie, Théorème de Bayes, Éléments de régulation transcriptionnelle.
English descriptors
- KwdEn :
- Analysis of Variance, Artifacts, Bayes Theorem, Binding Sites, Chromatin Immunoprecipitation, DNA-Binding Proteins (classification), DNA-Binding Proteins (metabolism), Oligonucleotide Array Sequence Analysis (methods), Regulatory Elements, Transcriptional, Software, Transcription Factors (classification), Transcription Factors (metabolism).
- MESH :
- chemical , classification : DNA-Binding Proteins, Transcription Factors.
- chemical , metabolism : DNA-Binding Proteins, Transcription Factors.
- methods : Oligonucleotide Array Sequence Analysis.
- Analysis of Variance, Artifacts, Bayes Theorem, Binding Sites, Chromatin Immunoprecipitation, Regulatory Elements, Transcriptional, Software.
Abstract
Sequence-specific transcription factors (TFs) regulate the expression of their target genes through interactions with specific DNA-binding sites in the genome. Data on TF-DNA binding specificities are essential for understanding how regulatory specificity is achieved.
DOI: 10.1093/bioinformatics/btt152
PubMed: 23559638
Affiliations:
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Le document en format XML
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Liu</name></author><author><name sortKey="Bulyk, Martha L" sort="Bulyk, Martha L" uniqKey="Bulyk M" first="Martha L" last="Bulyk">Martha L. Bulyk</name></author></analytic><series><title level="j">Bioinformatics (Oxford, England)</title><idno type="eISSN">1367-4811</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Artifacts</term><term>Bayes Theorem</term><term>Binding Sites</term><term>Chromatin Immunoprecipitation</term><term>DNA-Binding Proteins (classification)</term><term>DNA-Binding Proteins (metabolism)</term><term>Oligonucleotide Array Sequence Analysis (methods)</term><term>Regulatory Elements, Transcriptional</term><term>Software</term><term>Transcription Factors (classification)</term><term>Transcription Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de variance</term><term>Artéfacts</term><term>Facteurs de transcription ()</term><term>Facteurs de transcription (métabolisme)</term><term>Immunoprécipitation de la chromatine</term><term>Logiciel</term><term>Protéines de liaison à l'ADN ()</term><term>Protéines de liaison à l'ADN (métabolisme)</term><term>Sites de fixation</term><term>Séquençage par oligonucléotides en batterie ()</term><term>Théorème de Bayes</term><term>Éléments de régulation transcriptionnelle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>DNA-Binding Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA-Binding Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Oligonucleotide Array Sequence Analysis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term><term>Protéines de liaison à l'ADN</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Artifacts</term><term>Bayes Theorem</term><term>Binding Sites</term><term>Chromatin Immunoprecipitation</term><term>Regulatory Elements, Transcriptional</term><term>Software</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term><term>Artéfacts</term><term>Facteurs de transcription</term><term>Immunoprécipitation de la chromatine</term><term>Logiciel</term><term>Protéines de liaison à l'ADN</term><term>Sites de fixation</term><term>Séquençage par oligonucléotides en batterie</term><term>Théorème de Bayes</term><term>Éléments de régulation transcriptionnelle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sequence-specific transcription factors (TFs) regulate the expression of their target genes through interactions with specific DNA-binding sites in the genome. Data on TF-DNA binding specificities are essential for understanding how regulatory specificity is achieved.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Cambridge (Massachusetts)</li></settlement><orgName><li>Université Harvard</li></orgName></list><tree><noCountry><name sortKey="Bulyk, Martha L" sort="Bulyk, Martha L" uniqKey="Bulyk M" first="Martha L" last="Bulyk">Martha L. Bulyk</name><name sortKey="Liu, Jun S" sort="Liu, Jun S" uniqKey="Liu J" first="Jun S" last="Liu">Jun S. Liu</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Jiang, Bo" sort="Jiang, Bo" uniqKey="Jiang B" first="Bo" last="Jiang">Bo Jiang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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